发烧和皮疹病例的差异诊断结果对麻疹和红疹呈阴性,以补充监测活动
Clara Fappani1,2,3, Maria Gori1,3, Silvia Bianchi1,3
1Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
Journal of medical virology
|October 5, 2023
概括
为了改善麻疹和红疹的监测,多重PCR小组在丢弃的病例中确定了其他引起疹的病毒. 这种诊断方法提高了病毒检测率,并澄清了疑似麻疹-红疹病例的流行病学.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 消除麻疹病毒 (MV) 和红疹病毒 (RuV) 需要对疑似病例进行准确的诊断.
- 在意大利米兰,在978例 (2017年至今) 疑似麻疹和风疹病例中,有310例未经实验室证实.
- 调查这些废弃病例的其他疹相关病毒可以改善监测.
研究的目的:
- 为了确定八种常见的疹相关病毒病原体在麻疹和红疹丢弃病例中的患病率.
- 评估多重实时PCR面板在疑似麻疹和红疹病例中的差异诊断的实用性.
- 加强病毒监测和流行病学理解发烧性皮疹疾病.
主要方法:
- 在289个被丢弃的病例中,使用多重实时PCR试验进行了差异诊断.
- 该小组选了人类疹病毒6 (HHV-6) 和7 (HHV-7),帕尔沃病毒B19 (B19V),肠病毒 (EV),爱斯坦-巴尔病毒 (EBV),人类腺病毒 (HAdV),细胞巨型病毒 (HCMV) 和SARS-CoV-2.
- 检测到的病毒感染在不同年龄组和随着时间的推移而被分析.
主要成果:
- 在289例病例中,至少在188例 (65.1%) 中检测到八种目标病毒中的至少一种.
- 人类疹病毒7 (HHV-7) 是最频繁检测到的病毒.
- 多重组小组将总体病毒阳性病例识别率提高到87.5%,澄清了病毒病因和流行病学.
结论:
- 多重PCR面板是可疑麻疹和风疹病例差异诊断的有效工具,有助于最终分类.
- 实施此类小组可以通过识别更广泛的病毒病原体来加强监测活动.
- 这种方法提高了诊断准确度和流行病学见解,支持全球麻疹消除目标.
相关概念视频
Patterns of Fever
2.6K
Before understanding the types and patterns of fever, it is essential to know its phases.
2.6K
Types of Fever
387
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Here are the different types of fever:
387
Myocarditis II: Clinical Features and Diagnostic Tests
12
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
12
Methods of reducing fever
681
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
681
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
37
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
37
Increased Body Temperature
690
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
690


