相关实验视频

Updated: Jul 14, 2025

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent

Published on: May 8, 2017

小分子光探针用于炎症性疾病中的生物活性物种:关节炎,肺炎和肝炎

Xiaolei Zhang¹, Fuyan Tang¹, Wei Shu²

¹School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255000, P. R. China. haibinxiao@sdut.edu.cn.

|October 5, 2023

概括

本综述对小型分子光探针进行了分类,用于跟踪关节炎等炎症性疾病中的生物活性分子. 它强调了施工策略和成像应用,有助于未来用于炎症研究的探针开发.

科学领域:

生物医学成像技术生物医学成像技术
分子生物学分子生物学
化学生物学化学生物学

背景情况:

炎症是许多疾病的关键过程,由生物活性分子驱动.
检测这些分子对于理解炎症至关重要.
光成像为实时跟踪这些物种提供了一个强大的工具.

研究的目的:

系统地审查和分类小分子光探针用于炎症疾病中的生物活性物种.
概括探头构造策略和生物成像应用.
讨论未来在开发新的光探针炎症的挑战.

主要方法:

文献综述和现有关于光探针的炎症研究的综合研究.
基于目标生物活性物种 (例如,活性氧//硫物种,酶) 的探针分类.
对在关节炎,肺炎和肝炎等特定炎症条件下探针应用的分析.

主要成果:

在炎症研究中使用的小分子光探针的全面概述.
详细讨论探头设计原理及其在生物成像中的实用性.
确定关键的生物活性分子及其在炎症性疾病中的作用.

结论:

小分子光探针对于剖析炎症机制至关重要.
系统的分类有助于理解当前的能力和局限性.
需要在探针设计方面进行进一步的创新,以应对炎症疾病研究的未来挑战.

更多相关视频

In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles

In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles

Published on: May 2, 2014

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

相关概念视频

Immunofluorescence Microscopy

Immunofluorescence Microscopy

A fluorescence microscope uses fluorescent chromophores called fluorochromes, which can absorb energy from a light source and then emit this energy as visible light. Fluorochromes include naturally fluorescent substances (such as chlorophylls) and fluorescent stains that are added to the specimen to create contrast. Dyes such as Texas red and FITC are examples of fluorochromes. Other examples include the nucleic acid dyes 4’,6’-diamidino-2-phenylindole (DAPI), and acridine orange.

Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

Inflammation

Inflammation