抗高血压药物度测量与耐药高血压的个性化反相结合:一个随机对照试验
Laura E J Peeters1,2, M H W Kappers3, D A Hesselink2
1Erasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy.
Journal of hypertension
|October 5, 2023
概括
使用干燥血点检测的个性化反改善了对抗高血压药物的坚持,但没有显著降低抗性高血压. 这种方法可以提高药物服药,从而更好地控制血压.
科学领域:
- 药理学和治疗学 药理学和治疗学
- 临床试验设计 临床试验设计
- 高血压管理 高血压管理
背景情况:
- 对抗高血压药物 (AHDs) 的坚持对于血压 (BP) 控制至关重要.
- 抗性高血压 (RH) 在管理高血压方面构成了重大挑战.
- 识别不坚持是改善治疗结果的关键.
研究的目的:
- 通过干血斑点 (DBS) 采样来评估测量AHD度的有效性.
- 评估基于DBS结果的个性化反对RH的影响.
- 为了确定这种干预措施是否能改善AHD的坚持.
主要方法:
- 进行了一项多中心,随机,受控试验 (RHYME-RCT).
- 已确定的RH患者被随机分配到干预 (SoC + 个性化反) 或单独使用SoC.
- 在12个月后,使用DBS和BP测量评估了AHD坚持和RH患病率.
主要成果:
- 与标准护理手臂 (71.4%) 相比,干预手臂 (70.0%至92.5%) 的AHD坚持显著改善.
- 双臂之间粘附的差异在统计学上是显著的 (P=0.014).
- 虽然RH患病率在两个手臂都下降,但两组之间的差异在统计学上并不显著 (P=0.14).
结论:
- 使用DBS衍生的AHD度的个性化反有效地改善了药物坚持.
- 这种干预措施并没有导致抗性高血压患病率的统计显著降低.
- 与反相结合的DBS采样是监测和改善AHD遵守的一个有价值的工具.
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