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来自Ganoderma tsugae的抗菌兰诺斯坦三烯酸

Jiang Hu¹, Guo-Fen Li², Feng-Ming Xu³

¹College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.

Journal of Asian natural products research

|October 5, 2023

概括

研究人员从Ganoderma tsugae中发现了新的lanostane三类. 一种化合物,甘多德曼托醇,显示抗菌活性对抗格拉姆阳性细菌.

科学领域:

植物化学植物化学
自然产品化学化学
微生物学微生物学

背景情况:

甘菌种类是生物活性三烯酸的丰富来源.
来自Ganoderma的triterpenoids已经证明了各种药理性质,包括抗菌作用.
研究Ganoderma tsugae的化学成分可以导致发现新的化合物.

研究的目的:

从Ganoderma tsugae的果实体中分离和鉴定出新的和已知的兰三基.
评估隔离的三烯酸菌对病原性微生物的体外抗菌活性.

主要方法:

对Ganoderma tsugae果实体80%乙醇提取物的植物化学研究.
使用1D和2DNMR光谱 (1H-1H COSY,HMQC,HMBC) 进行化合物的隔离和结构阐明.
使用最小抑制度 (MIC) 值对六种致病微生物进行体外抗菌活性测试.

主要成果:

两种新的兰诺斯坦三类化合物,7.11-dioxo-3β-acetyloxy-26,27-dihydroxy-lanosta-8,24-diene (1) 和7.20-dioxo-3β-acetyloxy-11β,15α-dihydroxy-22,23,24,25,26,27-hexanorlanosta-8-ene (2) 已经被分离出来.
还确定了一种已知的兰诺斯坦三烯酸,甘多德曼托醇 (3).
化合物3对三种具有MIC值低于30μg/mL的グラム阳性细菌表现出抗菌活性.

结论:

这项研究成功地确定了来自Ganoderma tsugae的新型和已知的lanostane三烯酸.
甘三醇 (Ganodermanontriol) (3) 显示出作为一种抗菌剂对抗特定的格拉姆阳性病原体的潜力.
进一步研究这些三基的结构-活性关系可能会产生新的抗菌药物线索.

关键词:

甘树的 tsugae 是一个.这种植物是 Ganodermataceae.它具有抗菌活性,具有抗菌活性.拉诺斯坦三基化物拉诺斯坦三基化物

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