膀癌治疗后,尿路微生物组的形状是否发生变化?
Ahmed A Hussein1, Tariq A Bhat2, Zhe Jing2
1Department of Urology, A.T.L.A.S (Applied Technology Laboratory for Advanced Surgery) Program, Roswell Park Comprehensive Cancer Center, Elm & Carlton St, Buffalo, NY, 14263, USA. ahmed.aly@roswellpark.org.
World journal of urology
|October 5, 2023
概括
尿道微生物组在患有瘤和没有瘤的膀癌患者之间有所不同. 这项研究分析了经过尿道切除膀瘤 (TURBT) 后的尿道微生物组概况,揭示了无瘤与存在瘤的群体中不同的细菌组成.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 人们越来越认识到尿路微生物组在膀癌中的作用.
- 了解治疗后的微生物组变化对于患者管理至关重要.
研究的目的:
- 在经尿道切除膀瘤 (TURBT) 后,研究尿路微生物组特征的变化.
- 为了比较膀癌患者与没有瘤之间的尿道微生物组合.
主要方法:
- 从膀癌患者收集尿液样本.
- 使用16S rRNA测序分析了尿道微生物组.
- 评估了α和β多样性,以及细菌属的丰富性,并对共变量进行了调整.
主要成果:
- 尿路微生物组的β多样性在各组之间显著不同 (p=0.04).
- 在"瘤"组中,Veillonella和Bifidobacterium的数量更多.
- 在"没有复发瘤"组中,Escherichia-Shigella和Helococcus更为丰富.
结论:
- 没有复发或进展的膀癌患者与瘤患者相比,表现出明显的尿路微生物组特征.
- 这些发现强调了尿路微生物群作为膀癌管理中的生物标志物的潜力.
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