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Updated: Jul 14, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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Published on: December 1, 2020

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在针对 SARS-CoV-2 papain-like 蛋白酶的多站点药物优化中,透驱动的合作效应

Lili Duan1, Bolin Tang2, Song Luo2

  • 1School of Physics and Electronics, Shandong Normal University, Jinan, 250014, China. duanll@sdnu.edu.cn.

Cellular and molecular life sciences : CMLS
|October 5, 2023
PubMed
概括

优化药物GRL0617对SARS-CoV-2帕帕因样蛋白酶 (PLpro) 的作用通过合作性增强了结合亲和力. 分子模拟显示,变,特别是涉及关键残留物,驱动这种改善的相互作用,以改善药物开发.

关键词:
有约束力的自由能源.合作性 合作性 合作性输入力贡献 输入力贡献帕帕因类蛋白酶是一种类似帕帕因的蛋白酶.抑制剂的区域性改善

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