癌症患者的辐射相关心脏毒性查方面的进展
Walter Schiffer1,2, Lauren N Pedersen2,3, Matthew Lui1
1Cardiovascular Division, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave, CB 8086, St. Louis, MO, 63110, USA.
Current cardiology reports
|October 5, 2023
概括
放射治疗可能会导致心脏问题. 使用成像和生物标志物的早期查可以检测辐射诱导的心脏功能障碍 (RICD),并允许及时治疗以防止长期影响.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 放射治疗是癌症治疗的基石,显著提高了患者的生存率.
- 然而,放射治疗带有心血管副作用的风险,需要谨慎管理.
- 识别和减轻这些心脏影响对于优化患者的治疗结果至关重要.
研究的目的:
- 审查放射治疗对心血管的潜在影响.
- 讨论减少或管理辐射诱导心血管功能障碍 (RICD) 的策略.
- 突出查在RICD早期检测和干预中的作用.
主要方法:
- 针对RICD的初始查包括心脏回声心脏成像,MRI,CT扫描和托罗邦尼/尿素测量.
- 新的成像技术如PET和先进的MRI参数正在被探索.
- 新兴的生物标志物包括骨髓氧化酶,GDF-15,加勒素3,微RNA和代谢学.
主要成果:
- 目前的选方法可以识别已建立的RICD.
- 新型成像和生物标志物方法显示,有望更早,更具体地检测RICD.
- 这些进展可能能够识别亚临床RICD,为早期干预打开道路.
结论:
- 影像和生物标志物的进步为早期检测亚临床RICD提供了潜力.
- 早期识别可以导致及时治疗,减轻长期心血管并发症.
- 需要进行进一步的研究,以确定RICD的最佳查方式,生物标志物和监测策略.
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