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相关概念视频

COP Coated Vesicles00:59

COP Coated Vesicles

7.9K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
7.9K
Vaccinations01:51

Vaccinations

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Overview
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Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

3.5K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.5K
Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

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Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
7.0K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

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After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
389

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相关实验视频

Updated: Jul 14, 2025

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
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A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

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外膜膀 疫苗平台 外膜膀 疫苗平台

Francesca Micoli1, Roberto Adamo2, Usman Nakakana3

  • 1GSK Vaccines Institute for Global Health (GVGH) S.r.l., Siena, Italy. francesca.x.micoli@gsk.com.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
|October 5, 2023
PubMed
概括
此摘要是机器生成的。

外膜囊泡 (OMVs) 是有前途的疫苗平台,具有授权的疫苗和正在进行的临床开发. 基因工程和结合技术的进步提高了它们的多功能性,可以提供针对各种病原体的多种抗原.

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Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
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Expression and Purification of Virus-like Particles for Vaccination
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Expression and Purification of Virus-like Particles for Vaccination

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相关实验视频

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A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
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Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
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科学领域:

  • 细菌学 细菌学是一门学科.
  • 疫苗学 疫苗学 疫苗学
  • 生物技术是生物技术.

背景情况:

  • 外膜囊泡 (OMV) 是细菌的毒性因子,在低水平上自然产生的.
  • 化学提取或基因工程产生了用于疫苗开发的膜抗原 (GMMA) 的通用模块.
  • OMVs是一个经过验证的疫苗平台,拥有针对Neisseria meningitidis血清组B和Haemophilus influenzae型b的授权疫苗.

研究的目的:

  • 审查外膜囊泡 (OMV) 疫苗的进展情况.
  • 讨论授权的OMV疫苗和临床候选疫苗.
  • 探索OMV疫苗技术的最新趋势和未来方向.

主要方法:

  • 对授权的OMV疫苗和临床开发候选药物的审查.
  • 对基于OMV的疫苗的基因修饰和化学结合技术的分析.
  • 讨论使用OMV作为抗原载体的临床前研究趋势.

主要成果:

  • OMV疫苗对特定的细菌脑膜炎病原体有效.
  • 目前正在开发OMV作为异质抗原的载体,包括像SARS-CoV-2这样的病毒标.
  • 基因改造提高了OMV疫苗的安全性,反应性,免疫性和有效性.

结论:

  • OMV技术已经取得了显著的进步,使得多功能疫苗的开发成为可能.
  • 在广泛应用的OMV表面表达异质蛋白质仍然存在挑战.
  • 未来的研究应该专注于克服这些挑战,以扩大OMV疫苗的实用性.