相关实验视频
Updated: Jul 14, 2025

08:41
Porcine Normothermic Isolated Liver Perfusion
Published on: June 9, 2023
897
[勒卡尼迪平在热血动物中的分布]
L L Kvachakhiya1, V K Shormanov1
1Kursk State Medical University, Kursk, Russia.
Sudebno-meditsinskaia ekspertiza
|October 5, 2023
概括
这项研究跟踪了口服后大鼠中的勒卡尼迪平的分布. 勒卡尼迪平主要在胃和肠道中发现,这表明其在热血动物中的吸收和分布模式.
科学领域:
- 药理动力学和药物新陈代谢
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 勒卡尼迪平是一种通道阻塞剂,用于治疗高血压.
- 了解其在热血动物中的分布对于制药动力学分析至关重要.
研究的目的:
- 为了研究口服后Wistar大鼠中的勒卡尼迪平的分布.
- 在生物矩阵中验证量化lercanidipine的分析方法.
主要方法:
- 通过口服给大鼠服用半致命剂量的勒卡尼迪平 (890毫克/公斤).
- 使用乙,溶剂变化和宏列色谱,从组织和血液中分离勒卡尼迪平.
- 使用薄层染色学 (TLC),气体染色学-质谱学 (GC-MS) 和紫外线光谱学进行识别和量化.
主要成果:
- 勒卡尼迪平在各种组织中得到量化:胃含量 (198.183±29.541毫克/100克),胃 (195.312±21.579毫克/100克),小肠 (47.096±3.947毫克/100克),脏 (38.952±3.532毫克/100克) 和肝脏 (26.211±2.232毫克/100克).
- 分析方法在线性,选择性,准确性,精度和检测极限方面得到了验证.
结论:
- 该研究成功地建立并验证了在生物样本中分析勒卡尼迪平的方法.
- 证明了lercanidipine在口服后在老鼠的关键器官中的分布模式.
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