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Updated: Jul 14, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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TCR连接体强度对不同信号通路的PD-1抑制作用产生差异性影响

Waipan Chan1, Yuqi M Cao1, Xiang Zhao2

  • 1Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

The Journal of experimental medicine
|October 5, 2023
PubMed
概括

使用PD-1 (编程细胞死亡蛋白1) 和PD-L1的检查点阻塞疗法正在彻底改变癌症治疗. 我们的研究表明PD-1抑制向T细胞受体信号,受新抗原质量影响,改善癌症治疗的理解.

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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

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