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倾斜盘综合征中的深视神经头部形态及其对视觉损伤的临床影响
Eun Jung Lee1, Jong Chul Han1, Changwon Kee1
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Investigative ophthalmology & visual science
|October 5, 2023
概括
深视神经头部 (ONH) 的结构变化,特别是边缘组织角度和倾斜轴,与视网膜神经纤维层 (RNFL) 缺陷有关. 这些发现表明,ONH变形有助于RNFL损伤.
科学领域:
- 眼科医生 眼科 眼科
- 视神经头部成像 视神经头部成像
- 玻璃眼研究研究 玻璃眼研究
背景情况:
- 倾斜盘综合征 (TDS) 是一种光盘异常,可能与视野缺陷有关.
- 在TDS中了解深视神经头部 (ONH) 形态对于识别导致视网膜神经纤维层 (RNFL) 缺陷的因素至关重要.
研究的目的:
- 为了研究倾斜盘综合征 (TDS) 患者的深视神经头部 (ONH) 形态.
- 确定与TDS中RNFL缺陷存在相关的特定ONH结构因素.
主要方法:
- 放射性ONH光学连贯性断层扫描 (OCT) 用于评估TDS患者的光盘形状.
- 测量包括布鲁赫的膜开口 (BMO) - 前侧道开口 (ASCO) 偏移,边缘组织 (BT) 长度,深度和角度.
- 将TDS眼睛的参数与有或没有绿眼性RNFL缺陷的眼睛进行了比较.
主要成果:
- 与没有缺陷的眼睛相比,患有RNFL缺陷的眼睛显示了BMO-ASCO光盘边缘的更大的倾斜轴和更大的BMO-lamina cribrosa插入 (LCI) 角度.
- 在具有RNFL缺陷的眼睛中观察到较高的薄膜形 (LC) 缺陷的患病率.
- BMO-LCI角度和倾斜轴是与RNFL缺陷相关的重要因素,即使经过对眼内压力 (IOP) 和LC缺陷进行调整.
结论:
- 深度ONH边界组织角度和倾斜轴,按OCT测量,与TDS中的RNFL缺陷有关.
- 这些发现表明,结构ONH变形有助于RNFL缺陷的机制.
- 需要进一步的研究来阐明ONH结构在光盘倾斜在不同人群中的作用.
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