查头癌的方法,检测率和生存结果:系统性审查
Edward A Sykes1,2,3, Natalie Weisbrod1,4, Ella Rival1,5
1Odette Cancer Centre-Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
JAMA otolaryngology-- head & neck surgery
|October 5, 2023
概括
查头癌 (HNCs) 的查计划可以改善早期检测和整体存活率. 对口腔和鼻癌的风险向查显示出希望,但需要进一步的研究.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 头部和部癌症 (HNCs) 经常在晚期被诊断出来,限制了治疗选择和生存率.
- 查计划是改善HNCs早期检测和结果的潜在策略.
研究的目的:
- 系统地审查现有的HNC查计划在提高成年人诊断和生存率方面的有效性.
- 评估初级高企的普遍和风险准查方法.
主要方法:
- 按照PRISMA指南进行系统审查,搜索MEDLINE,Embase和Cochrane控制试验中心注册 (2001-2022年).
- 包括原始临床试验和对成人HNC查的观察性研究,并为其他文章提供雪球.
- 使用JBI批判性评估工具对所包含研究的质量评估.
主要成果:
- 审查了涉及470万成年人的16篇文章,大多数研究来自亚洲.
- 查,特别是口腔检查和爱斯坦-巴尔病毒检测,增加局部瘤的检测 (I/II阶段).
- 全面查改善了整体生存率,但没有改善癌症特异性生存率;有针对性的查提高了整体和癌症特异性生存结果.
结论:
- 对口腔和鼻癌的风险向查显示了改善诊断和患者生存的潜力.
- 建议对查遵守,成本效益和最佳风险分层进行进一步研究,特别是在非亚洲低发病率地区.
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