这是一项双盲,随机,安慰剂控制的研究,研究了CBN与CBD或不含CBD对睡眠质量的安全性和影响
Marcel O Bonn-Miller1, Matthew T Feldner1, Teah M Bynion1
1Canopy Growth Corporation.
Experimental and clinical psychopharmacology
|October 5, 2023
概括
每晚20毫克的大麻素 (CBN) 可以通过减少夜间唤醒和整体睡眠障碍来改善睡眠质量. 添加大麻 (CBD) 并没有增强这些睡眠益处.
科学领域:
- 药理学 药理学是指药理学的学科.
- 睡眠医学 睡眠医学
- 大麻素研究 研究 大麻素研究
背景情况:
- 睡眠障碍影响了相当一部分成人人口.
- Cannabinoids,如 cannabinol (CBN) 和 cannabidiol (CBD),正在研究它们对睡眠的潜在治疗作用.
- 之前关于大麻素和睡眠的研究已经产生了混合的结果,需要进一步的受控研究.
研究的目的:
- 评估单独的卡纳比诺 (CBN) 和其与大麻 (CBD) 的组合在提高主观睡眠质量的有效性.
- 确定CBN和CBD对特定睡眠参数的影响,包括睡眠开始的延迟时间,唤醒次数,睡眠开始后醒来 (WASO) 和白天疲劳.
主要方法:
- 这是一项双盲,随机,安慰剂对照试验,涉及293名参与者 (年龄在18-55岁之间),他们自我报告的睡眠质量差.
- 参与者接受了安慰剂,20毫克CBN或20毫克CBN与10毫克,20毫克或100毫克CBD组合连续七晚.
- 睡眠质量和其他睡眠参数使用经过验证的措施进行评估.
主要成果:
- 与安慰剂相比,单独服用20毫克CBN显示了改善睡眠质量的趋势 (p=0.082) 并显著减少了夜间唤醒的次数 (p=0.025) 和整体睡眠障碍 (p=0.023).
- 在任何治疗组中,没有观察到睡眠开始延迟,WASO或白天疲劳的显著差异.
- 添加CBD并没有为CBN对睡眠参数的影响提供额外的好处.
结论:
- 每晚服用20毫克大麻素 (CBN) 可能有效减少夜间醒来和整体睡眠障碍.
- 在这项研究中,大麻素 (CBD) 似乎没有增强CBN促进睡眠的影响.
- 需要进一步的研究来探索CBN对睡眠障碍的最佳使用.
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