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大分子拥挤剂对人类阿基因酶-I的结构和功能的影响,这是一种具有治疗意义的重要酶

Vineet Sadarangani1, Anjali Kalia1, Tasneem Kausar1

  • 1Protein Engineering Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.

The journal of physical chemistry. B
|October 5, 2023
PubMed
概括

大分子拥挤会影响人类的阿尔金酶-I酶活性和结构. 聚乙烯甘醇) 1000通过软相互作用显著降低活性,改变了酶的催化口袋和功能.

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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