母婴感染与儿童智力障碍之间的关联:系统性审查和元分析
Mahroo Rezaeinejad1, Seyed Mohammad Riahi2, Kimia Behzad Moghadam3
1Department of Obstetrics and Gynecology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
PloS one
|October 5, 2023
概括
怀孕期间母亲感染与儿童智力障碍 (ID) 的风险更高有关. 这一系统性审查证实了这种不同类型的研究之间的关联,强调了需要进一步的研究.
科学领域:
- 围产期流行病学 围产期流行病学
- 神经发育障碍 神经发育障碍
- 公共卫生 公共卫生
背景情况:
- 关于怀孕期间母亲感染与儿童智力障碍 (ID) 风险之间的联系,存在不一致的证据.
- 这次系统性审查和元分析旨在澄清这种关联.
- 了解这种关系对于母婴健康战略至关重要.
研究的目的:
- 系统地审查和分析有关孕期母亲感染和儿童智力障碍 (ID) 风险的现有研究.
- 综合证据并解决文献中的不一致问题.
- 提供协会的定量估计.
主要方法:
- 根据PRISMA和MOOSE的指导方针,搜索了主要的数据库 (Medline/PubMed,科学网,Embase,Scopus) 到2023年3月.
- 包括8项涉及超过130万参与者的研究,评估母亲感染和随后儿童ID风险.
- 使用随机效应模型将几率比率 (OR) 结合起来,并使用I2统计数据评估异质性.
主要成果:
- 怀孕期间母亲感染与儿童智力障碍 (ID) 风险显著增加有关 (OR,1.33;95% CI,1.21-1.46).
- 在基于ID和基于感染的研究设计的子组分析中,这种关联仍然显著.
- 当使用ICD代码诊断出孕产妇感染或ID时,也观察到一个显著的联系.
结论:
- 怀孕期间母亲感染与后代智力障碍风险增加有关.
- 这些发现在不同的研究设计和诊断标准中是一致的.
- 建议进行进一步的纵向研究,以确定因果关系并阐明潜在机制.
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