在双层乳液中纳米封装crocin,以提高稳定性和增强抗抑郁的有效性
1Food Quality and Safety Research Group, Food Science and Technology Research Institute ACECR, Mashhad, Iran.
PloS one
|October 5, 2023
概括
纳米封装增强了用于抑郁症治疗的克罗辛稳定性. 双层乳液与蛋白保护的crocin,显示有希望的感觉性质,当添加到巧克力.
科学领域:
- 食品科学与技术 食品科学与技术
- 营养保健品 营养保健品
- 化学工程是化学工程的重要组成部分.
背景情况:
- 抑郁症影响着人口的很大一部分,沙夫兰被认为是一种潜在的自然疗法.
- 沙夫兰中的关键化合物克罗辛具有抗抑郁作用,但由于环境因素而遭受不稳定问题.
- 纳米封装提供了一种有前途的策略,可以提高克罗辛的稳定性和生物可用性.
研究的目的:
- 开发和优化用于素纳米封装的双层乳液.
- 为了增强稳定性和控制crocin的释放.
- 评估素作为稳定剂的有效性,并评估素丰富巧克力的感官属性.
主要方法:
- 使用不同的表面活性剂比率,器速度和时间生产初级乳液.
- 使用大豆蛋白缩剂,阿拉伯和丁等稳定剂的高压均质化制造二次双层乳液.
- 评估乳液粘度,在模拟的胃肠道条件下释放crocin,以及丰富巧克力的感觉评估.
- 应用细胞自动机模型来预测素释放动力学.
主要成果:
- 最佳表面活性剂与水相比率被确定为100%,粘度与表面活性剂比率成比例增加.
- 在模拟的胃和肠道环境中,以点稳定的双层乳液表现出最高的粘度,并表现出最低的crocin释放率.
- 细胞自动机模型准确地预测了双层乳液中的克罗辛释放,可靠性为93-99%.
- 与对照样本相比,增强了双层乳液的巧克力获得了更高的感觉分数.
结论:
- 双层乳液,特别是用pectin稳定的乳液,有效地增强了crocin的稳定性并控制了其释放.
- 开发的纳米封装技术适合将crocin纳入巧克力等食品中.
- 细胞自动机模型为预测素释放提供了可靠的工具,有助于配方优化.
- 这种方法有可能开发功能性食物,改善抑郁症管理的治疗效益.
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