患有PCOS的女性的瘦肉量和相关因素,具有不同的表型
Tayane Muniz Fighera1,2,3, Betânia Rodrigues Dos Santos1,4, Poli Mara Spritzer1,2,4
1Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
PloS one
|October 5, 2023
概括
多囊性卵巢综合征 (PCOS) A和B表型与更高的瘦肉质有关,与胰岛素,雄激素,脂肪质量和骨密度有关. 这表明影响PCOS妇女肌肉质量的关键因素.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 身体组成分析 身体成分分析
背景情况:
- 多囊性卵巢综合征 (PCOS) 与肥胖,胰岛素抵抗和代谢问题有关.
- 这些因素对不同PCOS表型肌肉质量的具体影响尚不清楚.
研究的目的:
- 为了研究不同PCOS表型的临床和荷尔蒙特征和瘦体质之间的关系.
- 为了确定与PCOS妇女的瘦身量相关的因素.
主要方法:
- 一项涉及133名具有不同PCOS表型和对照的生育年龄妇女的病例控制研究.
- 进行了临床,代谢和荷尔蒙评估.
- 使用双能X射线吸收计,用肌素作为间接瘦肉质量标记物的身体组成进行了评估.
主要成果:
- 与对照组相比,A型和B型 (超类) 的BMI,代谢综合征,雄激素,胰岛素耐药性 (HOMA-IR),脂肪质量和骨矿物质密度 (BMD) 较高.
- 尾肌瘦质量指数 (ALMI) 在表型A和B中高于对照,但与表型C没有显著差异.
- 在A和B类表型中,ALMI与肌素,胰岛素,自由雄激素指数 (FAI),脂肪质量指数 (FMI) 和骨 BMD 总量正相关.
结论:
- 禁食胰岛素,FAI,脂肪质量和全大腿骨 BMD 与患有 PCOS 表型 A 和 B 的女性的肌肉质量增加有关.
- 这些发现突出了PCOS中瘦身质量的特定代谢和荷尔蒙驱动因素.
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