毛细管流MRI:在复杂分散中量化微观合作性
Klaudia W Milc1, Thomas Oerther2, Joshua A Dijksman3,4
1Laboratory of Biophysics, Wageningen University, 6708 WE Wageningen, The Netherlands.
Analytical chemistry
|October 5, 2023
概括
一个新的磁共振成像 (MRI) 速度测量平台精确地测量了受限复杂流体中的流量. 这项技术准确地量化了3D打印和化品中使用的材料中的粒子相互作用和流动行为.
科学领域:
- 流体动力学 流体动力学
- 生物物理学的生物物理.
- 材料科学 材料科学 材料科学
背景情况:
- 在3D打印和化品等应用中,有限的颗粒液体流量至关重要.
- 预测复杂流体中的合作流需要用于光学不透明介质的先进成像技术.
研究的目的:
- 开发一种高分辨率,压力驱动的磁共振成像 (MRI) 速度测量平台,用于局部分析受限复杂流体的流量.
- 在各种复杂的流体系统中量化合作流现象和非局部粒子相互作用.
主要方法:
- 一个压力驱动的MRI速度测量平台是使用压力控制器和具有可调壁性能和直径 (100-540μm) 的毛细血管开发的.
- 高空间分辨率 (9微米) 允许量化流合作长度尺度 (ξ) 到15微米的卡博波尔和脂肪晶体分散 (FCD).
主要成果:
- 该平台在Carbopol (颗粒大小d ~ 2μm) 中量化流合作长度尺度时实现了13%的准确性.
- 对于 Carbopol, ξ 是独立于流量条件的;对于 FCD, ξ 随着间隙大小和压力 (0.25-1 bar) 的增加而增加.
- 非局部相互作用涉及2-8个粒子,较小的域在较高的限制下占主导地位.
结论:
- 开发的流动MRI平台是研究受限复杂流体动态的多功能工具.
- 该平台对超高场的可扩展性为化学分辨速度测量和3D打印和体外研究中的应用提供了潜力.
相关概念视频
Magnetic Resonance Imaging
5.2K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.2K
Capillarity in Fluid
230
Capillarity describes the movement of liquid in small spaces without external forces acting on it. The capillarity is driven by surface tension and adhesive interactions between the liquid and surrounding solid surfaces. This effect is often seen in narrow tubes, porous materials, and fine particles.
Surface tension is crucial to capillarity. It results from cohesive forces between liquid molecules at the liquid-air boundary, forming a skin that resists external forces. When the capillary tube...
Surface tension is crucial to capillarity. It results from cohesive forces between liquid molecules at the liquid-air boundary, forming a skin that resists external forces. When the capillary tube...
230
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
101
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
101


