孕产妇便秘与后代的过敏性鼻炎有关:全国一项回顾性队列研究
Ming-Hung Lee1, Meng-Che Wu2,3,4,5, Yu-Hsun Wang6
1Department of Otorhinolaryngology Head and Neck Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
PloS one
|October 5, 2023
概括
怀孕期间母亲的便秘与婴儿过敏性鼻炎 (AR) 的风险更高有关. 这项研究强调了监测便秘的孕妇对潜在的婴儿健康结果的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 过敏性鼻炎 (AR) 是全球普遍存在的亚托皮性疾病.
- 婴儿便秘与亚托皮性疾病的风险增加有关.
- 母亲的肠道微生物群可能在婴儿发育和免疫反应中发挥作用.
研究的目的:
- 调查怀孕期间母亲便秘与后代患AR风险之间的关联.
- 扩大早期生命暴露的概念,包括子宫内时期.
- 评估母亲便秘对儿童AR风险的影响.
主要方法:
- 一项基于人口的队列研究,使用台湾国家健康保险研究数据库 (2005-2015).
- 确定了102,820名患有便秘的母亲,并将其与102,820名对照人进行匹配.
- 使用倾向得分匹配和考克斯回归分析来调整混因素.
主要成果:
- 在患有便秘的母亲的孩子中,童年AR的发病率为每1000人年83.47.
- 在调整为共变量后,患有便秘的母亲的孩子患AR的风险增加了1.20倍.
- 孕产妇便秘与儿童AR风险增加有显著的关联.
结论:
- 怀孕期间母亲的便秘是儿童过敏性鼻炎发展的重要危险因素.
- 这一发现强调了解决孕妇便秘问题的重要性.
- 需要进一步研究将母体肠道健康与婴儿形症联系在一起的机制.
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