长非编码RNA:与糖尿病相关的并发症中隐藏的参与者
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Mutah University, Al-Karak, Jordan.
Diabetes & metabolic syndrome
|October 5, 2023
概括
长非编码RNAs (lncRNAs) 调节糖尿病 (DM) 并发症中的基因表达. 特定的lncRNAs是上调或下调,影响氧化应激和炎症等途径.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 内分泌学 在内分泌学.
背景情况:
- 长非编码RNAs (lncRNAs) 是人类疾病中的关键基因表达调节者.
- 糖尿病是一种具有严重血管并发症的代谢障碍.
- lncRNAs与DM相关的并发症有关,这些并发症影响胰腺β岛,脏病,视网膜病,心肌病和神经病.
研究的目的:
- 审查 lncRNAs 在糖尿病相关并发症中的作用.
- 为了识别参与DM病变发生的特定lncRNAs.
- 探索这些 lncRNAs 的分子机制和基因标.
主要方法:
- 在Scopus数据库 (2014-2023) 中进行了广泛的文献搜索.
- 包括关于 lncRNAs 和糖尿病并发症的评论文章.
- 统计分析和发现的总结.
主要成果:
- 发现包括ANRIL,MALAT1和HOTAIR在内的几种lncRNA在各种糖尿病并发症中被上调.
- 其他lncRNAs,如H19,MEG3和GAS5,显示下调.
- lncRNAs MALAT1,ANRIL,MIAT,MEG3,H19和HOTAIR因其参与多种并发症而被确定为具有潜在意义的.
结论:
- lncRNAs是DM相关并发症的关键调节者,表达因疾病背景而异.
- 这些lncRNAs主要向包括氧化应激,炎症,亡,纤维化和血管生成在内的途径.
- 了解lncRNA的作用为治疗糖尿病并发症提供了潜在的治疗点.
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