肝炎E病毒感染和肝细胞癌的风险:系统性审查和元分析
1Department of Interventional Therapy, Zibo First Hospital, Zibo 255200, China.
Cancer epidemiology
|October 5, 2023
概括
肝炎E病毒 (HEV) 感染与肝细胞癌 (HCC) 的更高风险有关. 这一元分析证实了HEV感染和HCC发育增加之间存在显著的关联,特别是与健康对照人群相比.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 肝炎E病毒 (HEV) 感染和肝细胞癌 (HCC) 之间的联系仍然不太了解和争论.
- 之前的研究还没有充分研究HEV在HCC发展中的潜在作用.
研究的目的:
- 进行观察性研究的元分析,以确定HEV感染是否会增加HCC的风险.
- 巩固现有证据,关于HEV和HCC之间的关联.
主要方法:
- 在主要数据库 (PubMed,科学网,Embase,Scopus) 进行了全面的文献搜索,截至2023年5月1日.
- 使用随机效应模型,从七项符合条件的研究中汇集了几率比率 (OR) 和95%置信区间 (95%CI).
- 使用埃格尔测试,漏斗图,灵敏度和累积分析来评估出版偏差和结果稳定性.
主要成果:
- 包括7项研究,包括1873例HCC病例和8679例对照.
- 在HEV感染和HCC风险之间发现了统计学上显著的关联 (OR 1.94;95%CI 1.26-3.0).
- 当使用健康对照组 (OR 2.28) 时,这种关联仍然显著,但当使用慢性肝病患者作为对照组 (OR 1.66) 时,并非如此.
结论:
- 患有HEV感染的个体表现出患HCC的风险增加.
- 需要进一步严格的临床和实验研究来验证这些发现.
- 研究各种HEV基因型对HCC促进的差异影响是有必要的.
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