血中素度和血中LPS检测在重症患者中是一个前性观察性研究
Claire Chaignat1, Laurent Lagrost2, Karena Moretto3
1Medical Intensive Care Unit, Besançon University Hospital, Besançon, France.
Journal of critical care
|October 5, 2023
概括
败血症患者的血中素水平下降,与脂聚糖化物 (LPS) 水平无关. 在重症患者中,腹部败血症显示较高的LPS活性.
科学领域:
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 败血症可以诱导肠道功能障碍,肠道可以是败血症的来源.
- 血中素是肠细胞质量的标记物.
- 血脂多糖 (LPS) 是一种潜在的细菌转移标记物.
研究的目的:
- 在重症患者中调查血素和血LPS之间的相关性.
- 评估败血症和这些生物标志物之间的关系.
主要方法:
- 对109名进入ICU的危急病患者进行前性研究.
- 在ICU入院时测量血中素和血LPS度和活性.
- 在ICU入院时,有和没有败血症的患者的比较.
主要成果:
- 血中素和血LPS度或活性之间没有发现相关性.
- 败血症患者的血中素水平显著降低 (13.4μmol/L对比21.3μmol/L,p=0.02).
- 在腹部败血症中,与腹外败血症相比,等离子体LPS活性更高 (1.04EU/mL对比0.63,p=0.01).
结论:
- 血中素与LPS水平无关,但在败血症患者中降低.
- 在重症患者中,LPS无处不在.
- 腹部败血症与血LPS活性增加有关.
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