选择性/偏向性/多目标性μ/δ/κ阿片类受体的小分子配体的历史观点和最近的进展 (2019-2022)

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Ye He1, Qian Su2, Liyun Zhao1

  • 1Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Bioorganic chemistry
|October 5, 2023
PubMed
概括

研究人员正在开发新的阿片类止痛药,以减少呼吸系统抑郁和成等副作用. 本综述侧重于针对阿片类受体 (MOR/DOR/KOR) 的新型选择性,偏向性和多向性连接体,以改善疼痛管理.

关键词:
止痛药 止痛药是一种止痛药.有偏见的阿片类药物多目标阿片类药物多目标阿片类药物有选择性的阿片类药物.在 μ/δ/κOR 中.

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