-相互作用通过促进细胞壁上的化促进尼古提亚烟草L.的毒性减少
Lili Qu1, Zicheng Xu1, Wuxing Huang1
1College of Tobacco Science, Henan Agricultural University, National Tobacco Cultivation and Physiology and Biochemistry Research center, Key Laboratory for Tobacco Cultivation of Tobacco Industry, Zhengzhou, Henan, China.
Journal of hazardous materials
|October 5, 2023
概括
和 (Se-Mo) 的联合处理增强了植物细胞壁,以化危险的 (Cr). 这种分子机制增强了pectin,cellulose和lignin,改善了植物修复和食品安全.
科学领域:
- 环境科学 环境科学
- 植物生物学 植物生物学
- 生物化学 生物化学
背景情况:
- (Cr) 是一种有毒的重金属,对植物和动物产生影响.
- (Se) 和 (Mo) 是已知的减轻重金属毒性的微量营养素.
- 植物细胞壁内Cr化中的Se-Mo相互作用的分子机制尚不清楚.
研究的目的:
- 为了研究Se-Mo相互作用对Cr亚细胞分布的影响.
- 分析细胞壁中的Cr化,包括组成,结构和功能组.
- 进行全面的转录组分析,以了解分子反应.
主要方法:
- 用50μM Cr处理植物,有或没有Se-Mo.
- 分析Cr在芽和根的积累,专注于细胞壁的部分.
- 与细胞壁生物合成相关的基因表达分析 (转录组).
- 里埃变换红外光谱 (FTIR) 用于细胞壁功能组分析.
主要成果:
- 细胞壁积累了显著的Cr (51.0%在芽中,65.0%在根中),pectin是主要的结合成分.
- 通过Se-Mo治疗,提高了参与pectin和纤维素生物合成的基因 (GAUT,UGP,GALE).
- 通过对素生物合成基因 (CAD,POX,PAL) 的上调,Se-Mo治疗增加了素含量和细胞壁厚度.
- 经过FTIR分析,Se-Mo处理后细胞壁中碳酸盐酸组 (-COOH) 的增加,增强了Cr化.
结论:
- Se-Mo相互作用增强植物细胞壁成分 (pectin,纤维素,红素) 来化.
- 参与多糖和素生物合成的特定基因的升级是这种机制的关键.
- 细胞壁中碳酸基的增加有助于增强Cr的结合.
- 结果提供了关于植物修复策略的见解,并改善了有关重金属污染的食品安全.
相关概念视频
Sulfur Assimilation
21
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
21
Antidotes
664
Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
664
Mutagenicity and Carcinogenicity
1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K
Cholinergic Antagonists: Pharmacokinetics
500
Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations, while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...
500


