气泡云的特征和二次频率内在值基因组三的切除效率
Connor Edsall1, Laura Huynh2, Timothy L Hall3
1Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, 325 Stanger St., Blacksburg, VA, 24061, United States of America.
Physics in medicine and biology
|October 5, 2023
概括
双频组织缩通过控制腔化气泡云来增强组织剥离. 与单频方法相比,这种方法提高了损伤精度和切除效率.
科学领域:
- 生物医学工程 生物医学工程
- 声学物理 声学物理
- 医疗器械 医疗器械
背景情况:
- 组织缩是一种非热聚焦的超声波组织切除技术.
- 声波化气泡云是组织的组织破坏机制的关键.
- 除效率取决于气泡云的大小和密度.
研究的目的:
- 研究双频脉冲对气泡云动态和废弃效率的影响.
- 探索不同脉冲到达时间如何影响洞腔.
- 评估红细胞幻影中病变的形成和效率.
主要方法:
- 使用一个模块化500kHz:3MHz的组织缩转换器.
- 使用双频脉冲,压力比为1:1.
- 改变了3 MHz脉冲相对于500 kHz脉冲的到达时间.
- 使用高速光学成像进行空洞化分析.
- 在阿加洛斯和红细胞幻影中评估了病变的形成.
主要成果:
- 双频气泡云的大小与单频结果是中间的.
- 脉冲到达时间调节了气泡云的大小和动态,早期到达产生了均的膨胀/崩.
- 红细胞幻影实验产生了精确的病变,面积更小,切除效率更高.
- 双频组织缩显示了比单频方法更好的消去效率.
结论:
- 双频基因组会有效调节泡云的动态.
- 这种调制允许精确的损伤生成.
- 与单次频率组织缩相比,实现了更高的切除效率.
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