硫化和硫化剂或硫药剂:在临床前和临床研究中的分类,差异和相关性
A Martelli1, R d'Emmanuele di Villa Bianca2, G Cirino2
1Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy; Interdepartmental Research Center "Nutrafood: Nutraceutica e Alimentazione per la Salute", University of Pisa, 56126 Pisa, Italy; Interdepartmental Research Center "Biology and Pathology of Ageing", University of Pisa, 56126 Pisa, Italy.
Pharmacological research
|October 5, 2023
概括
硫化 (H2S) 是一个重要的信号分子. 新的术语"硫化药品"和"硫酸硫化药品"将食品中的硫化合物分类为用于健康研究和补充剂的化合物.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 营养保健品 营养保健品
背景情况:
- 三十年来,硫化 (H2S) 被认为是生物系统中至关重要的信号分子.
- 研究利用各种H2S捐赠体,包括无机盐和有机化合物,研究其生理作用.
- 食品中天然存在的硫化合物因其释放H2S的特性和相关的健康益处而受到越来越多的研究.
研究的目的:
- 为分类含硫化合物而引入和定义"硫化药品"和"硫化药品"的术语.
- 建立一个框架来根据它们的来源和研究和补充中的应用来分类这些化合物.
- 为了突出人们对食品衍生的硫化合物作为H2S捐赠者的兴趣日益增长.
主要方法:
- 关于硫化信号和H2S捐赠者的现有文献的审查.
- 在食品中作为H2S捐赠体的天然硫化合物的表征.
- 制定含硫物质的分类系统.
主要成果:
- 确定特定的食品衍生硫化合物作为强大的H2S捐赠者.
- 确定"硫黄药品" (更广泛的类别) 和"硫药品" (食品衍生品) 的术语.
- 证明这些术语在组织研究和产品开发中的实用性.
结论:
- 拟议的术语为硫化合物提供了明确的分类,基于其来源和H2S释放潜力.
- "硫中药"是开发促进健康的食补充剂的一个有希望的领域.
- 这种分类有助于导航涉及H2S释放化合物的临床前和临床研究.
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