剧烈的体力炼可以通过基位的激活来改善识别记忆,但不能通过腹膜区域激活来改善
Karine Ramires Lima1, Ben-Hur Souto das Neves1, Guilherme Salgado Carrazoni1
1Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of Pampa, Uruguaiana, RS, Brazil.
Physiology & behavior
|October 5, 2023
概括
急性体力炼 (PE) 增强了老鼠的新型物体识别 (NOR) 记忆持久性. 这种记忆的改善取决于心脏部位 (LC),但不是腹膜区域 (VTA).
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 运动生理学 运动生理学
背景情况:
- 已知急性体力炼 (PE) 对动物和人类的记忆巩固有影响.
- 之前在老鼠身上进行的研究表明,PE增强了新型对象识别 (NOR) 记忆的持久性,与海马体多巴胺和诺亚上腺素有关.
- 其他大脑区域的作用,特别是腹膜区域 (VTA) 和心脏部位 (LC),在PE诱导的记忆增强中仍然未得到充分探索.
研究的目的:
- 调查VTA和LC在调节急性PE后NOR记忆持久性的参与.
- 为了确定VTA或LC是否对急性PE的增强记忆效果至关重要.
主要方法:
- 老鼠接受了NOR训练,随后进行了30分钟的跑步机炼.
- 在运动后向VTA或LC注入载体 (VEH) 或肌肉醇 (MUS).
- 1,7,14天后对记忆回忆进行了评估;对照组接受了没有PE的VEH,MUS或NMDA.
主要成果:
- 急性PE显著增强了NOR记忆持续时间长达14天.
- 这种效应模仿了NMDA对VTA或LC的谷氨酸刺激.
- 用MUS损坏NOR编码阻止LC,表明其对于PE诱导的记忆改善的必要性;VTA阻塞没有任何效果.
结论:
- 剧烈的体力炼可以在特定时间范围内改善学习和记忆.
- 脑位 (locus coeruleus,LC) 对于急性PE增强记忆效果至关重要.
- 这种PE诱导的记忆调制不需要腹部 tegmental 区域 (VTA).
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