在什么程度上白质映射到双相情感障碍的认知? 对证据的系统审查
Georgia F Caruana1, Sean P Carruthers2, Michael Berk3
1Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria 3053, Australia.
Progress in neuro-psychopharmacology & biological psychiatry
|October 5, 2023
概括
双相情感障碍 (BD) 的认知障碍与白质 (WM) 完整性有关. 在WM中,特别是体中,较高的分数异质性与BD患者的更好的注意力和执行功能相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 认知障碍是双相情感障碍 (BD) 的一个关键特征,但它的神经基础,特别是关于白质 (WM) 的神经基础,尚未得到充分理解.
- 之前关于WM与 BD认知之间的关系的研究由于方法上的差异导致了不一致的结果.
研究的目的:
- 系统地综合现有关于双相情感障碍中白质和认知之间的关系的研究.
- 澄清这些协会的性质和范围.
- 确定最佳实践和未来的研究方向.
主要方法:
- 系统审查37项遵循PRISMA指南的横截面研究.
- 对研究白质宏观结构和微观结构与 BD 的认知功能相关的研究进行分析.
- 评估研究中的方法异质性和临床变异性.
主要成果:
- 有证据表明,白质完整性和BD的认知功能之间存在关系.
- 全球和体中分数异质性 (FA) 的增加与复杂的注意力和执行功能的增强有关.
- 然而,一些研究没有发现显著的关联,在更大的样本研究和使用后期区域选择的研究中,效应更明显.
结论:
- 白质完整性,特别是像FA这样的微观结构性质,似乎与双相情感障碍的认知表现有关.
- 需要进一步研究更大的样本大小,标准化的方法和增加的统计能力来澄清这些复杂的关系.
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