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相关概念视频

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

266
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
266
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

199
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
199
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

137
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
137
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
341
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
161
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
464

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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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在炎症性肠道疾病中改变了基于voxel和基于表面的形态学.

Jennifer Kornelsen1, Theresa McIver2, Md Nasir Uddin3

  • 1Department of Radiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Winnipeg Health Sciences Centre, Winnipeg, MB, Canada; University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada.

Brain research bulletin
|October 5, 2023
PubMed
概括

研究了炎症性肠病 (IBD) 中的大脑结构差异. 患有IBD的成年人与对照人群相比,表现出显著的左侧化皮质稀薄和更大的皮质复杂性.

关键词:
大脑结构 大脑结构皮层复杂性 皮层复杂性皮层厚度 皮层厚度克罗恩氏病是什么 克罗恩氏病是什么IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD炎症性肠病是一种炎症性肠病.基于表面的形态测量.性结肠炎是一种基于voxel的形态测量方法

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科学领域:

  • 神经成像是一种神经成像.
  • 胃肠病学 胃肠病学
  • 大脑-肠子轴研究研究

背景情况:

  • 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,涉及胃肠道炎症和脑肠轴功能障碍.
  • 神经成像研究对于了解IBD患者的脑肠相互作用和并发症至关重要.

研究的目的:

  • 使用多种神经成像指标,与健康对照人群相比,研究IBD成人大脑结构的差异.
  • 探索IBD患者疾病持续时间和大脑结构之间的关系.

主要方法:

  • 使用基于voxel的形态测量和基于表面的形态测量来评估灰色物质体积,皮质厚度,化,皮质复杂性和深度.
  • 在72名患有IBD的成年人和90名健康对照人群中比较了大脑结构指标.

主要成果:

  • 重要发现包括IBD组的左侧化皮质稀薄和左侧状和右后侧带带状回路的皮质复杂性增加.
  • 两组之间没有观察到灰质体积,化或深度的显著差异.
  • 后期分析显示,在IBD队列中,疾病持续时间和右上边皮质皮质复杂性之间存在关联.

结论:

  • 大脑结构的变化,特别是皮质稀薄和复杂性变化,在IBD的成年人中存在.
  • 这些发现突显了IBD对大脑结构的影响,并支持了大脑-肠轴受损的概念.