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手部骨关节炎:一个新鲜的外观

Pascal Richette¹, Augustin Latourte¹

¹Service de rhumatologie, hôpital Lariboisière, Paris, France.

Joint bone spine

|October 5, 2023

概括

手部骨关节炎 (OA) 针对炎症的治疗方法,包括生物药物和DMARD,在很大程度上失败了. 一项小型试验显示,口服普雷尼松可为手部炎症性OA爆发提供短期缓解.

科学领域:

类风湿病学类风湿病学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

手部骨关节炎 (OA) 是一种常见的疾病,对其成像和治疗干预措施进行了大量研究.
图像学研究突出显示了协同炎,子冠状腺胀和手手关节疼痛之间的联系.
近年来,人们越来越关注了解手部OA的炎症成分.

研究的目的:

对手部症状性骨关节炎的最新治疗策略的疗效进行审查.
评估随机对照试验 (RCT) 的结果,调查生物药物和常规疾病修饰性抗风湿药物 (DMARDs).
评估炎症在手部OA病原和治疗反应中的作用.

主要方法:

随机对照试验 (RCT) 的系统审查,重点是手部OA治疗.
对评估抗类素 (IL) -1,抗瘤亡因子 (TNF) 和抗IL-6药物的试验分析.
包括试验评估传统的DMARDs,如氧化和短期皮质类固醇使用.

主要成果:

涉及生物药物 (抗IL-1,抗TNF,抗IL-6) 和氧化的多个RCT在症状手部OA方面没有比安慰剂显著的益处.
六个评价生物药物的RCT没有在症状或结构有效性方面表现出优于安慰剂的优势.
一项积极的试验表明,10毫克口服普雷迪尼松6周有效治疗手部OA发作与突炎,但这不是一个长期的解决方案.

结论:

目前的生物和常规DMARD疗法在很大程度上对治疗症状手部OA无效.
炎症在手部OA的症状爆发中起作用,正如前尼松试验的积极结果所证明的那样.
虽然短期使用皮质类固醇可以缓解炎症爆发,但由于潜在的副作用,不建议长期治疗手部骨质炎症.

关键词:

手手手的手的手.图像成像技术可以提供图像.骨关节炎是一种骨关节炎.治疗方法治疗方法

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