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叶酸-奇托桑功能化聚合物纳米载体用于治疗结肠癌

Navya Ajitkumar Bhaskaran¹, Srinivas Reddy Jitta², Salwa²

¹Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India; Department of Pharmaceutics, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mithibai College Campus, Gate No. 2, V.M. Road, Vile Parle (W), Mumbai 400056, Maharashtra, India.

International journal of biological macromolecules

|October 5, 2023

概括

聚合物纳米粒子 (PNPs) 已开发用于口服结肠癌,用于输送素 (IRI) 和素 (QT). 未涂层的PNP增加了结肠中的IRI度,为静脉注射治疗提供了可行的替代方案.

科学领域:

纳米技术纳米技术
药品制造药品制造药品制造
在瘤学瘤学.

背景情况:

结肠癌的治疗通常依赖于静脉注射化疗,这可能会导致全身副作用.
有针对性的药物输送旨在提高治疗效率和降低毒性.
叶酸受体在许多结肠癌细胞上过度表达,使它们成为药物输送的潜在目标.

研究的目的:

开发口服聚合物纳米颗粒 (PNPs) 装有虹素素 (IRI) 和素 (QT) 用于向结肠癌的治疗.
与未涂层PNP相比,评估表面修饰的 (叶酸-基托) PNP (C-FA-PNP) 的疗效和生物分布.

主要方法:

聚合物纳米粒子被合成并以大小,形态和药物封装为特征.
进行了体外药物释放,细胞系研究 (Caco2) 和体内药理学和生物分布研究.
表面修饰涉及将PNP涂上色素-叶酸合物.

主要成果:

PNPs证明了对IRI和QT的高捕获效率,并持续释放药物.
细胞系研究表明C-FA-PNPs在Caco2细胞上的优越性.
在体内研究表明PNP和C-FA-PNP的疗效相似,但未涂层PNP与市场上销售的产品相比,在结肠中显著增加IRI度.

结论:

开发的PNP配方提供了一个有希望的口服替代品,用于肠癌的静脉注射虹素.
虽然表面修饰的目标是向,但未涂层的PNP在体内显示出优异的结肠药物递送.
需要进一步的研究来优化结肠癌治疗的向输送系统.

关键词:

联合交付联合交付设计实验的设计.氨酸是一种氨酸.这是一种P-glycoprotein蛋白.聚合物纳米粒子聚合物纳米粒子奎尔丁 (Quercetin) 是一种青素.癌症癌症癌症癌症癌症结肠结肠结肠结肠是什么意思

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