长效可注射多用途预防技术,用于预防艾滋病毒和意外怀孕
Isabella C Young1, Aryani Pallerla2, Mackenzie L Cottrell3
1Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
概括
新的多用途预防技术 (MPT) 植入物将艾滋病毒预防 (dolutegravir或cabotegravir) 与避孕 (etonogestrel或medroxyprogesterone acetate) 结合起来,提供90天的保护.
科学领域:
- 生物医学工程 生物医学工程
- 药理学 药理学是指药理学的学科.
- 生殖健康 生殖健康
背景情况:
- 避孕套是预防艾滋病毒和意外怀孕的唯一有效方法.
- 避孕套使用的挑战包括用户接受度差以及合作伙伴缺乏合作,限制其有效性.
研究的目的:
- 开发一种可注射,超长效应,可生物降解和可拆卸的现场成型植入物 (ISFI) 作为多用途预防技术 (MPT).
- 在ISFI中,将抗逆转录病毒药物 (dolutegravir或cabotegravir) 与激素避孕药 (etonogestrel或medroxyprogesterone acetate) 共同配制.
主要方法:
- 用抗逆转录病毒药物和避孕药物组合的MPTISFI的配方.
- 在小鼠体内测试以评估耐受性和局部/全身炎症.
- 90天内抗逆转录病毒和避孕药的血度的药理动力学分析.
- 药物释放动力学和植入物可移除性的评估.
主要成果:
- 所有ISFI配方在小鼠中都能耐受,没有慢性炎症的迹象.
- 90天内,卡博特格拉维尔和多卢特格拉维尔在血中的持续度高于保护水平 (4×PA-IC90).
- 90天内可量化的乙乙和乙乙的血度.
- 植入物移除后,美德基酸的快速清除,而卡博特格拉维尔的清除不完全.
结论:
- 在耐受良好的ISFI中,证明了抗逆转录病毒药物和避孕药的成功联合配方.
- 在长达90天的时间内达到活性剂的持续血度.
- 开发的ISFI代表了多用途预防的有希望的新方法.
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