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Updated: Jul 14, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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LncRNA SPRY4-IT1通过DUSP6-ERK1/2-Chk1信号通路调节由颗粒物诱导的16HBE细胞恶性转变

Yanli Li1, Dan Tang1, Jian Zhang1

  • 1State Key Laboratory of Respiratory Disease, Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, 511436, PR China.

Chemosphere
|October 5, 2023
PubMed
概括

暴露于颗粒物会通过改变细胞功能触发肺癌. 该研究发现,长非编码RNA SPRY4-IT1 作为瘤抑制剂,通过调节DUSP6-ERK1/2-Chk1通路来逆转这些有害影响.

关键词:
DUSP6-ERK1/2-Chk1 的意思是恶性转变的恶性转变颗粒物质颗粒物质是什么在cRNA SPRY4-IT1 中.

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