预防性抗生素用于可选初级整关节置换的全国变化
Ahmed Mabrouk1, Alexander Abouharb1, Gabriel Stewart1
1Leeds Teaching Hospitals NHS Trust, St. James's University Hospital, Leeds, UK.
Bone & joint open
|October 5, 2023
概括
英国医院在关节和膝关节置换术的预防性抗生素治疗方案中显示出显著的差异,这影响了感染风险和遵守指南. 这项研究强调了对标准化抗生素预防的需要,以减少周围假肢关节感染 (PJIs).
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 在选择性初级全关节和膝关节关节整形手术中,预防性抗生素的使用在英国医院之间有很大差异.
- 这种变化可能会影响周围假肢关节感染 (PJI) 的风险.
研究的目的:
- 为了确定当前的抗生素预防方案,选择性初级关节整形在英国.
- 分析这些方案的变化及其对PJI风险的潜在影响.
- 评估遵守抗生素预防的国际共识指南.
主要方法:
- 对医院和信任网站以及MicroGuide应用程序进行了全面的搜索,以确定预防性抗生素治疗方案.
- 每种治疗方案的成本是使用英国国家表单 (BNF) 数据来计算的.
- 治疗方案与2018年费城共识指南进行了比较.
主要成果:
- 观察到主要和替代预防性抗生素治疗方案和剂量的广泛差异.
- 一些常见的疗法没有覆盖手术部位感染 (SSI) 的可能原因,例如缺乏 *Enterococcus* 覆盖的 cefuroxime.
- 2018年费城共识指南的遵守是有限的,大多数中心不包括一种头.
结论:
- 在推的抗微生物预防中存在广泛的差异,用于英国医院的初级关节整形术.
- 目前的做法可能无法充分覆盖常见的病原体,可能会增加PJI风险.
- 显然需要更多的标准化和遵守国际准则.
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