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肺神经内分泌瘤中的索马托斯塔丁受体表达:对DOTATATE PET扫描的分析

Taymeyah Al-Toubah¹, Jaime Montilla-Soler², Ghassan El-Haddad²

¹Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida; and.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

|October 5, 2023

概括

大多数转移性肺神经内分泌瘤 (NETs) 在DOTATATE PET扫描上显示非均的体静止素受体 (SSTR) 表达. 这种异质性使它们不太适合用于SSTR向治疗,例如受体放射性核酸治疗.

科学领域:

核医学是一种核医学.
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

在转移性肺神经内分泌瘤 (NETs) 中,索马托斯塔丁受体 (SSTR) 表达需要更好的表征.
了解SSTR表达对于评估肺 NET中的SSTR向治疗至关重要.

研究的目的:

用DOTATATE PET成像来描述转移性肺 NET 中SSTR表达的程度和均性.
根据成像发现,确定适合SSTR向治疗的肺 NET患者的比例.

主要方法:

对48名患有转移性肺 NET 的患者进行了回顾性审查,这些患者接受了68Ga或64Cu-DOTATATE PET 影像检查.
对DOTATATE PET扫描进行分析,以评估SSTR表达水平 (负,弱,均,异质).

主要成果:

四名患者 (8%) 的SSTR表达是负的,10名患者 (21%) 的表达非常弱.
在剩余的34名患者中,有21名 (占总数的44%) 呈现出均的SSTR阳性表达,而13名 (占总数的27%) 呈现异质表达.
只有44%的患者均呈阳性受体表达,这表明他们适合接受受体放射性核酸治疗.

结论:

大多数转移性肺 NET 呈现异质或不足的SSTR表达.
在转移性肺 NET 中,SSTR 均表达不常见,这限制了它们对 SSTR 向治疗的候选人.
仔细评估SSTR表达统一性对于指导肺 NET患者的治疗决策至关重要.

关键词:

64Cu-DOTATATE 的使用情况 68Ga-DOTATATE 的使用情况肺 NETs 的肺部网络.神经内分泌瘤的神经内分泌瘤索马托斯塔丁的表达方式

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