在三项前性研究中,产前化物暴露与学校年龄的认知表现的剂量依赖关系
Philippe Grandjean1,2, Alessandra Meddis3, Flemming Nielsen1
1Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark.
European journal of public health
|October 5, 2023
概括
高度化物暴露可能会损害儿童的发育. 一项对1500多对母婴对进行的研究发现,产前化物水平与较低的智商之间存在联系,这表明需要保护.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 怀孕期间化物暴露是神经发育的一个潜在问题.
- 以前的研究表明,化物与发育神经毒性之间存在联系.
- 从多个队列中整合数据,可以进行更可靠的剂量效应评估.
研究的目的:
- 调查产前化物暴露与儿童智商之间的剂量效应关系.
- 将Odense Child Cohort (OCC) 的数据与墨西哥和加拿大的现有研究结合起来.
- 为了确定与神经发育影响相关的化物暴露的基准度.
主要方法:
- 对母亲的尿样进行了化物度分析.
- 儿童智商在7岁时使用儿童韦克斯勒智力表进行评估.
- 来自三个队列 (>1500个母婴对) 的数据被组合在一起,以计算联合基准度 (BMC) 和下置信限值 (BMCL).
主要成果:
- 奥登斯儿童队列 (OCC) 没有显示尿液化物与智商之间的显著关联.
- 对所有三个队伍的联合分析显示,产前化物暴露与儿童智商之间存在统计学上显著的关联.
- 发育性神经毒性的联合基准度与较低的保证值 (BMCL) 为0.28 mg/l.
结论:
- BMCL 表明,化物暴露导致发育神经毒性的潜在门.
- 结果表明,孕妇和儿童可能需要保护免受过度化物暴露.
- 需要进一步的研究来证实这些发现,并为公共卫生指南提供信息.
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