肺移植后患者对elexacaftor/tezacaftor/ivacaftor的看法
Dave Young1, Lauren E Bartlett2, Jennifer Guimbellot2
1Department of Biology, University of Washington, Seattle, WA 98195, United States.
概括
患有囊性纤维化 (CF) 的肺移植接受者知道elexacaftor/tezacaftor/ivacaftor (ETI),但担心药物相互作用和副作用. 他们希望与他们的医生分享有关ETI使用的决策.
科学领域:
- 肺部病理学 肺部病理学
- 移植医学 移植医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 囊性纤维化跨膜导电调节器 (CFTR) 调节器,如elexacaftor/tezacaftor/ivacaftor (ETI),已经改变了CF护理.
- 患有CF的肺移植接受者 (LTR) 是一个独特的人群,对他们对ETI治疗的看法数据有限.
研究的目的:
- 评估CF的LTRs对ETI使用的认识,感知和担忧.
- 了解影响LTR开始ETI治疗的决定的因素.
主要方法:
- 在单个肺移植计划中,对81名患有CF的LTR进行了调查.
- 46名参与者 (58%) 完成了调查,报告了ETI意识,认为治疗非肺部CF症状的重要性,以及对ETI的担忧.
主要成果:
- 大多数受访者 (88%) 知道ETI,超过80%认为治疗非肺部CF症状很重要.
- 关键问题包括潜在的与免疫抑制剂的药物相互作用 (77%),副作用 (53%),成本 (49%) 和缺乏特定于LTR的临床试验数据 (43%).
- 一半的参与者表示,如果他们的CF或移植医生推,他们只会考虑ETI,强调需要共享决策.
结论:
- CF LTRs对外来感染有意识,但表达了重大担忧,特别是与移植药物的相互作用以及医生指导的需要.
- 调查结果强调了解决LTRs特定问题的重要性,并促进对这一群体的ETI治疗进行知情,共享的决策过程.
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