患者报告的肌肉症状及其特征在高血压患者群体中有资格接受他类药物治疗:一项探索性研究
Riccardo Sarzani1, Massimiliano Allevi1, Federico Giulietti2
1Internal Medicine and Geriatrics, IRCCS INRCA, Ancona, Italy; Department of Clinical and Molecular Sciences, University "Politecnica delle Marche", Ancona, Italy.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|October 5, 2023
概括
患者报告的肌肉症状在高血压患者中很常见,通常归因于像他类药物这样的药物. 然而,这些症状经常与衰老和其他因素有关,而不仅仅是使用他类药物.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 在临床实践中,与他类药物相关的肌肉症状 (SAMS) 被认为是常见的.
- 高血压患者经常报告肌肉症状归因于药物或营养食品.
- 本研究调查了这些患者报告的肌肉症状 (PRMS) 的患病率和特征,重点关注他类药物的使用.
研究的目的:
- 在高血压患者中评估患者报告的肌肉症状 (PRMS) 的患病率和特征.
- 为了确定与其他药物/营养药物使用相比,他类药物的使用是否与PRMS特别相关.
- 在这个人群中探索影响PRMS的因素.
主要方法:
- 一项观察性研究涉及390名连续高血压门诊患者.
- 患者被问及药物/营养药物诱导的肌肉症状.
- 修改后的静止素相关肌肉症状临床指数 (SAMS-CI) 用于评估.
主要成果:
- 48.5%的患者报告PRMS,而他类药物使用者与非使用者之间没有显著差异.
- 年龄和服用药物的数量与PRMS有显著的关联.
- 虽然症状发作和改善时间与他类药物治疗有关,但整体患病率并非如此.
结论:
- 患者报告的肌肉症状在高血压患者中非常普遍,通常归因于药物,包括他类药物.
- 这些症状经常与衰老有关,可能受到nocebo/drucebo效应或其他条件的影响.
- 这些发现表明,PRMS可能过度归因于他类药物,突出了差异诊断的必要性.
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