在患有缺血性中风的年轻患者中,肝纤维化和中风复发之间的关联
Xinyi Zhu1, Jie Gao1, Kang Yuan1
1Department of Neurology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|October 5, 2023
概括
通过纤维化-4评分评估的晚期肝纤维化,显著增加了年轻成年人的中风复发风险. 这一发现凸显了肝纤维化作为这一人口中风预后的关键因素.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 神经学 神经学
背景情况:
- 在年轻人中,中风的发病率正在增加.
- 肝纤维化是心血管事件和中风的已知危险因素.
- 肝纤维化对年轻成年人中风预后的影响尚不清楚.
研究的目的:
- 研究年轻成人中风患者肝纤维化与中风复发风险之间的关联.
- 确定肝纤维化是否影响年轻人中风的长期预后.
主要方法:
- 对有史以来首次缺血性中风的年轻人进行潜在的招生.
- 使用纤维化-4 (FIB-4) 评分评估肝纤维化,分为三个级别.
- 使用考克斯回归模型对中风复发和分析的随访.
主要成果:
- 在长达3.1年的时间里,621名患者中有11.6%的患者经历了复发性中风.
- 患有高FIB-4评分的患者显示,中风复发的可能性明显更高 (HR 3.748,P=0.011).
- 在对混因素进行调整后,FIB-4得分仍然是中风复发的独立预测指标.
结论:
- 年轻中风患者的晚期肝纤维化与复发性中风的风险增加有关.
- 肝纤维化评估,特别是使用FIB-4得分,可以帮助分层化中风风险.
- FIB-4评分是预测年轻成年人中风复发的一个有价值的工具.
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