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在辅助生殖技术中的myo-inositol从长椅到床边

Andrea Etrusco¹, Antonio Simone Laganà², Vito Chiantera³

¹Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy; Unit of Obstetrics and Gynecology, 'Paolo Giaccone' Hospital, Palermo, Italy.

Trends in endocrinology and metabolism: TEM

|October 5, 2023

概括

肌酸伊诺西托 (myo-inositol (myo-ins)) 改善了女性和男性的生殖功能,与D-chiro-inositol (D-chiro-ins) 相反. 本审查支持在多囊性卵巢综合征 (PCOS) 管理中使用辅助生殖技术 (ART) 的myo-ins.

科学领域:

生殖内分泌学生殖内分泌学
代谢障碍代谢障碍代谢障碍
伊诺西生物化学伊诺西生物化学

背景情况:

内醇是胰岛素敏感化化合物,具有治疗多囊性卵巢综合征 (PCOS) 的潜力.
肌肉内醇 (myo-ins) 对于男性和女性的生殖过程至关重要,包括卵子,精子和胚胎的发育.
卵巢中D-chiro-inositol (D-chiro-ins) 水平升高可能会对卵细胞质量产生负面影响.

研究的目的:

审查有关异醇在生殖功能中的作用的文献.
评估myo-inositol在辅助生殖技术 (ARTs) 中的临床疗效.
为了比较myo-inositol和D-chiro-inositol对生殖健康的影响.

主要方法:

系统的文献审查关于内醇和生殖的研究.
在PCOS和ART中分析关于myo-inositol和D-chiro-inositol的数据.
对影响卵细胞和精子质量的证据的评估.

主要成果:

肌肉中性醇对女性和男性生殖参数具有有益影响.
有证据支持在ART协议中使用myo-inositol.
由于可能对卵细胞质量产生不良影响,D-chiro-inositol的作用需要仔细考虑.

结论:

米奥伊诺西托是改善生殖结果的有前途的治疗剂.
对于患有PCOS的患者,鼓励在ART中临床应用myo-inositol.
进一步的研究可能会澄清不同的异醇异构体的不同作用和最佳使用.

关键词:

D-chiro-inositol 的使用方法辅助生殖技术是一种辅助生殖技术.在体外受精体外受精.不孕不育不孕不育不孕不育肌肉中毒醇 (myo-inositol) 是一种多囊性卵巢综合征多囊性卵巢综合征

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