[糖尿病和阻塞性睡眠呼吸暂停:一个病例对照研究]
Romina Abelleira1, Carlos Zamarrón1, Vanessa Riveiro1
1Servicio de Neumología, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España.
概括
阻塞性睡眠呼吸暂停 (OSA) 与糖尿病 (DM) 和糖尿病前期 (preDM) 有关. 年龄,夜间低氧化和过度白天嗜睡 (EDS) 预测DM,而BMI和AHI预测OSA患者的糖尿病前期.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 心血管医学 心血管医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和糖尿病 (DM) 是普遍存在的,并且经常共存.
- 它们的联合存在增加了心血管并发症的风险.
- 经常低诊断OSA和DM/糖尿病前期 (preDM) 之间的关联.
研究的目的:
- 调查OSA和DM/preDM之间的关联.
- 在OSA患者中确定DM和DM前的独立预测因子.
主要方法:
- 采用了一种随机的病例控制研究设计.
- 参与者根据年龄,性别和体重指数 (BMI) 进行了匹配.
- 收集的数据包括爱普沃思睡眠度量得分,呼吸暂停-呼吸暂停指数 (AHI) 和氧气脱度指数.
主要成果:
- 与对照组 (10.1%) 相比,OSA患者中DM的患病率明显高 (18.8%).
- 在OSA组 (41.8%) 和对照组 (10.6%) 中,糖尿病前期的患病率也显著增加.
- 59.6%的OSA患者报告过度的白天嗜睡 (EDS),而对照组为24.5%.
结论:
- OSA与DM和DM前两种疾病都有显著的关联.
- 在OSA患者中,DM的独立预测因素包括年龄,夜间低氧症和EDS.
- BMI和AHI被确定为患有OSA的个体中糖尿病前期的预测因素.
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