动态功能连接性变化与精神病特征和库辛病的认知缺陷相关
Zhebin Feng1, Haitao Zhang2, Tao Zhou1
1Department of Neurosurgery, Chinese PLA General Hospital, Haidian District, Beijing, PR China.
Translational psychiatry
|October 5, 2023
概括
库辛病 (CD) 患者的动态大脑连接性变化与认知和情绪缺陷有关. 在CD患者中改变的网络动态可能有助于解释他们的症状并帮助诊断.
科学领域:
- 神经内分泌学神经内分泌学
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
背景情况:
- 库希氏病 (CD) 是一种罕见的神经内分泌疾病,其特点是皮质醇过多,导致认知障碍和精神症状.
- 以前使用休息状态fMRI的研究已经在CD患者中发现了静态大脑连接异常.
- 动态功能连接 (dFNC) 和它与CD认知和情绪缺陷的关联在很大程度上仍未被探索.
研究的目的:
- 在CD患者中调查默认模式网络 (DMN),突出网络 (SN) 和中央执行网络 (CEN) 中的动态功能连接异常.
- 探索动态大脑连接特征与CD的认知缺陷和精神病理症状之间的关系.
- 评估dFNC特征在将CD患者与健康个体分类方面的潜力.
主要方法:
- 在50名CD患者和57名健康对照中利用休息状态fMRI和动态功能连接 (dFNC) 方法.
- 专注于DMN,SN和CEN的分析,它们以其在认知情感过程中的作用而闻名.
- 采用k-means集群来识别不同的dFNC状态并分析停留时间,网络之间的连接以及与临床措施的相关性.
主要成果:
- 与对照组相比,CD患者在特定的dFNC状态中表现出改变的停留时间 (在状态1中更多,在状态4中少).
- 停留时间的群体差异与CD患者的认知缺陷有显著的关联.
- DMN和SN之间的互联网连接,以及状态4的参与时间,与焦虑/抑郁负相关,与认知表现正相关.
结论:
- 这项研究揭示了库辛病患者大脑动态功能连接的显著异常.
- 动态大脑网络特征与CD中观察到的认知障碍和情绪症状有关.
- dFNC分析显示,作为一种工具,它有望对CD患者进行分类,并了解其缺陷的神经生物学基础.
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