与视野或结构进展相关的因素在前性研究中首次发生,该研究对未经治疗的开角玻璃眼病患者进行,眼内压力正常
Rei Sakata1, Makoto Araie2,3, Takeshi Yoshitomi4
1Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan. reisakata-tky@umin.ac.jp.
Eye (London, England)
|October 5, 2023
概括
磁盘出血 (DH) 预测在低眼内压 (IOP) 的开角玻璃眼 (OAG) 视野损失之前的结构损伤. 老年与结构变化之前的视野损失有关.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 视网膜成像分析分析
背景情况:
- 与较低的正常眼内压力 (IOP) 相结合的开角玻璃眼 (OAG) 呈现出独特的诊断挑战.
- 了解结构性与功能性恶化的序列对于及时干预至关重要.
研究的目的:
- 为了确定预测结构损伤 (磁盘/视网膜) 之前视野 (VF) 损失 (结构第一) 的因素.
- 确定预测低IOP的OAG中结构损害之前的VF损失 (Field First) 的因素.
主要方法:
- 在90名OAG患者的前性队列研究中,IOP<15 mmHg超过5年.
- 定期的IOP测量,汉弗里场分析仪 (HFA) 测试和立体底部摄影.
- 多变量考克斯比例危险模型分析了进展模式.
主要成果:
- 场第一个恶化发生在49%的眼睛中,结构第一个在33%中.
- 磁盘出血 (DH) 与结构第一恶化 (P=0.006) 有意义地相关.
- 年龄较大与第一个领域的恶化有显著的关联 (P=0.040).
结论:
- 在低内压的OAG中,DH是视野损失之前结构损伤的关键预测因子.
- 年龄的增加是结构变化之前视野恶化的重要因素.
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