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针对达尔巴万辛的注射效应:附加单剂量达普托米辛

Razieh Kebriaei^1,2, Jacinda C Abdul-Mutakabbir^1,3, Kyle C Stamper^1,4

¹Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.

Infectious diseases and therapy

|October 5, 2023

概括

结合达尔巴万辛 (DAL) 和单剂达普米辛 (DAP),即使在高细菌负载下,也能有效地消灭耐药的金黄色葡萄球菌菌株. 这种组合克服了DAL.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

达普托米辛 (DAP) 是抗万科米辛感染的替代品,但可能导致DAP非敏感 (DNS) 菌株.
达尔巴万辛 (DAL) 是一种脂糖,对抗性黄金葡萄球菌表现出活性,但对高细菌注射剂的有效性较低.
这项研究调查了最小的DAP剂量是否可以增强DAL对高注射量耐药菌株的疗效.

研究的目的:

为了评估达尔巴万辛 (DAL) 和达普米辛 (DAP) 单疗法与它们的结合治疗对抗高注射量耐药金黄色葡萄球菌的疗效.
确定单剂量DAP是否可以减轻DAL.观察到的注射剂效应.

主要方法:

使用了微稀释和单间PK/PD模型.
测试了三个耐药菌株 (两个DNS-VISA,一个MRSA) 的高 (10^9 CFU/mL) 和低 (10^7 CFU/mL) 初始注射量.
评估了168小时的DAL和DAP单疗法和组合疗法.

主要成果:

单剂疗法在高注射量时没有杀菌作用.
DAL单一疗法在高与低注射量之间显示出效率降低.
将DAL与单次DAP剂量结合使用表明,在高注射量下增强了细菌杀死.

结论:

达尔巴万辛的注射效应是治疗高细菌负载的一个重大挑战.
将达尔巴万辛与一次剂量达普托米辛结合使用,有望在根除耐药黄金葡萄球菌菌株方面发挥作用.
这种组合策略对于具有大量细菌负担的感染可能是可行的选择.

关键词:

组合疗法是一种联合疗法.达尔巴万辛 (Dalbavancin) 是一种葡萄酒.在高水平的注射剂中.

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