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在NAFLD中的肝脏内皮细胞和过渡到NASH和HCC

Rallia-Iliana Velliou¹, Aigli-Ioanna Legaki¹, Polyxeni Nikolakopoulou¹

¹Department of Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527, Athens, Greece.

Cellular and molecular life sciences : CMLS

|October 5, 2023

概括

肝脏侧状内皮细胞 (LSEC) 功能障碍促进非酒精性脂肪肝疾病 (NAFLD) 进展到炎症和癌症. 恢复LSEC健康可能会逆转肝损伤并预防并发症.

科学领域:

肝病学和代谢疾病
内皮细胞生物学内皮细胞生物学
肝脏病理生理学肝脏病理生理学

背景情况:

非酒精性脂肪性肝病 (NAFLD) 是代谢综合征的肝脏表现,影响全球数百万人.
NAFLD可以发展为非酒精性脂肪肝炎 (NASH),肝纤维化,肝硬化和肝细胞癌 (HCC).
肝脏状内皮细胞 (LSEC) 对于肝功能至关重要,具有抗炎和抗纤维性质.

研究的目的:

审查LSECs在NAFLD病原和进展中的关键作用.
总结有关在NAFLD,NASH和HCC发育中的LSEC功能障碍的证据.
要突出恢复LSEC恒温的治疗潜力,以治疗NAFLD.

主要方法:

在体外和体外实验研究的全面审查.
对NAFLD中LSEC功能的人类临床数据的分析.
在NAFLD进展过程中对LSEC表型变化的当前知识的综合.

主要成果:

在生理条件下,LSEC 维持肝脏平衡.
在NAFLD期间,LSEC经历了毛细化,失去保护功能并促进肥胖症,炎症和纤维化.
LSEC功能障碍是NASH和HCC发展的关键驱动因素.

结论:

LSEC 功能障碍是NAFLD进展及其严重并发症的核心原因.
准和恢复LSEC平衡是一种有前途的治疗策略.
对LSEC向疗法的进一步研究可以逆转肝损伤并预防NAFLD相关的结果.

关键词:

肝细胞癌是肝细胞癌.肝脏肝脏肝脏肝脏非酒精性脂肪肝疾病是非酒精性脂肪肝疾病.非酒精性脂肪性肝炎的疾病.鼻状内皮细胞鼻状内皮细胞

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