利用更高的植物遗传学洞察力来发现抗等离子体药物
Phanankosi Moyo1, Luke Invernizzi1, Sephora M Mianda1
1Biodiscovery Center, Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag X 20, Hatfield, Pretoria, 0028, South Africa.
Natural products and bioprospecting
|October 5, 2023
概括
疟疾的耐药性需要新的治疗方法. 这项研究使用了基于植物的植物遗传学分析来识别有希望的植物序列和家族,以发现新的抗疟疾化合物.
科学领域:
- 植物化学 植物化学
- 药用化学 医学化学
- 药物发现 药物发现 药物发现
背景情况:
- 抗疟疾药物耐药性对疟疾控制工作构成重大威胁.
- 植物为开发新的抗疟疾药物提供了丰富的新型化学支架来源.
研究的目的:
- 通过植物遗传学分析确定可以优先考虑抗疟疾药物发现的更高植物序列和家族.
- 为了加速从植物来源发现新的抗等离子体化合物.
主要方法:
- 在PubMed数据库中查询了具有抗质性质的天然化合物.
- 植物物种被分配到分类家族和分类顺序;化合物的抗性指数,选择性指数和物理化学性质计算.
- 遗传学树与生物数据相关联,以确定有前途的种类.
主要成果:
- 确定了Caryophyllales,Buxales和Chloranthales作为抗疟疾药物发现的顶级植物订单.
- 确定Ancistrocladaceae,Simaroubaceae和Buxaceae作为顶级植物家族.
- 这些种类中的高活性化合物 (IC50 ≤ 1 μM) 具有独特的结构,与现有的抗疟疾药物不同.
结论:
- 优先考虑特定的植物序列和家族可以加速寻找强效和安全的抗疟疾药物候选药物.
- 已识别的种类代表了发现新型,类似药物的抗疟疾分子的宝贵资源.
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