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在SLE中准DORIS缓解和LLDAS:一项审查

Agner R Parra Sánchez¹, Ronald F van Vollenhoven², Eric F Morand³

¹Amsterdam Rheumatology Center ARC, Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Centre, Amsterdam, The Netherlands. a.r.parrasanchez@amsterdamumc.nl.

Rheumatology and therapy

|October 5, 2023

概括

在全身性红斑狼 (SLE) 中实现低疾病活性 (LLDAS) 或缓解 (DORIS) 改善了患者的治疗结果. 将这些作为治疗到目标目标的实施可能会提高与标准方法相比的护理.

科学领域:

类风湿病学类风湿病学
免疫学免疫学免疫学
临床医学临床医学

背景情况:

系统性红斑狼 (SLE) 治疗的目标是缓解,由SLE (DORIS) 中缓解的定义标准定义.
在临床实践中,实现DORIS缓解是罕见的.
狼低疾病活动状态 (LLDAS) 为SLE患者提供了更可实现的目标.

研究的目的:

审查SLE中DORIS和LLDAS定义的演变.
检查证据支持实现DORIS或LLDAS的临床益处.
讨论在SLE管理中将DORIS和LLDAS作为处理到目标 (T2T) 目标的实施.

主要方法:

在SLE中对DORIS和LLDAS的研究的文献综述.
临床试验和现实世界关于缓解和低疾病活性状态的数据的分析.
在慢性炎症疾病中讨论治疗目标原则.

主要成果:

无论是DORIS缓解还是LLDAS都与SLE的积极临床结果有关.
治疗到点的方法在其他炎症疾病中显示出更好的结果.
证据支持在SLE患者中实现DORIS或LLDAS的好处.

结论:

对于一个比DORIS缓解更广泛的SLE群体,LLDAS提供了一个务实的和可实现的治疗目标.
将DORIS和LLDAS作为T2T目标的实施有可能改善SLE患者的治疗结果.
需要进一步的试验来确认使用DORIS/LLDAS在SLE中的T2T策略的疗效.

关键词:

多里斯的缓解缓解这就是LLDAS.疾病活动较低的疾病活动.减免减免减免系统性红血性狼 (Systemic lupus erythematosusus) 是一种全身性狼.处理到目标的方法.

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