RAD51是一种不良的预后标志物,是口腔状细胞癌的潜在治疗标
Yu-Fen Tsai1,2,3, Leong-Perng Chan4,5,6, Yuk-Kwan Chen7,8
1Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
Cancer cell international
|October 5, 2023
概括
过度表达RAD51表明口腔癌的预后不佳,促进对化疗和放射治疗的耐药性. 与B02一起抑制RAD51可以增强西斯丁的作用.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 过度表达RAD51与各种癌症的预后不佳有关.
- 它在口腔状细胞癌 (OSCC) 中的作用需要进一步研究.
- 研究RAD51作为OSCC治疗点的潜力.
研究的目的:
- 调查RAD51在OSCC中的预后意义.
- 为了确定RAD51是否影响抗化疗和放射治疗的耐药性.
- 在OSCC中评估RAD51作为潜在的治疗点.
主要方法:
- 免疫组织化学染色评估了OSCC患者的RAD51蛋白质表达.
- 使用lentiviral向量来操纵RAD51的表达 (敲击/过度表达).
- 在体外测试中评估了细胞活力,细胞亡和瘤球形成,治疗后使用化疗剂,照射和RAD51抑制剂B02.
主要成果:
- 在OSCC患者中,较高的RAD51表达与较差的存活率相关,特别是那些接受辅助治疗的患者.
- 在OSCC细胞中,RAD51过度表达增强了对化疗和放射治疗的耐药性.
- 与RAD51抑制剂B02和西斯普拉丁的同时治疗显著增加了癌细胞细胞毒性,与单独使用西斯普拉丁相比.
结论:
- 在口腔状细胞癌中,RAD51作为一个不良的预后标志物.
- 增加RAD51蛋白表达与治疗耐药性有关.
- 向RAD51,可能与像B02这样的抑制剂一起,可能会改善口腔癌的治疗结果.
关键词:
B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02 B02耐化疗和放射治疗的耐药性 耐化疗和放射治疗的耐药性口腔状细胞癌的癌症.在RAD51中使用RAD51.更多相关视频
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