相关实验视频
Updated: Jul 14, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.7K
甲状腺功能障碍,自身免疫性甲状腺疾病和类风湿性关节炎疾病严重程度之间的关联
Mohammad Amin Yazdanifar1, Mahsa Bagherzadeh-Fard2, Mohammad Amin Habibi1
1Qom University of Medical Sciences, Qom, Iran.
BMC endocrine disorders
|October 5, 2023
概括
自身免疫性甲状腺疾病 (AITD) 和抗甲状腺过氧化酶 (anti-TPO) 阳性与增加类风湿性关节炎 (RA) 疾病严重程度有关. 这些情况在经历严重疾病活动的RA患者中更为普遍.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 和自身免疫性甲状腺疾病 (AITD) 经常因共同的自身免疫性病原体而共存.
- 了解AITD对RA严重性的影响对于全面的患者管理至关重要.
研究的目的:
- 调查甲状腺功能障碍,抗甲状腺过氧化酶 (抗TPO) 抗体阳性,AITD和RA疾病严重程度之间的关联.
- 分析伊朗人口中的这些关联.
主要方法:
- 一项涉及350名RA患者的横截面研究,在伊朗科姆的第三级护理中心进行.
- 数据收集包括医疗记录,采访,体检和实验室测试.
- 使用DAS-28-ESR得分评估RA疾病活动,将患者分类为缓解,轻度至中度和严重的疾病活动组.
主要成果:
- 与缓解期患者相比,严重的RA患者的抗TPO抗体阳性是严重的RA患者的2.93倍 (P < 0.001).
- 与缓解期患者相比,患重型RA的患者患AITD的可能性是2.71倍 (P < 0.001),甲状腺功能障碍的可能性是82% (P = 0.006).
结论:
- 甲状腺功能障碍,抗TPO抗体阳性和AITD与RA疾病严重程度的增加显著相关.
- 这些发现凸显了甲状腺疾病查在RA患者的重要性,特别是那些有严重疾病活动的患者.
相关概念视频
Autoimmune Disorders
471
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
471
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
37
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
37
Rheumatic Heart Disease I: Introduction
14
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
14
Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K

