调查睡眠特征与急性心肌梗塞风险之间的因果相互作用:孟德尔的随机化研究
Nikhil Arora1,2, Laxmi Bhatta3,4,5, Eivind Schjelderup Skarpsno6,7
1K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway. nikhil.arora@ntnu.no.
BMC medicine
|October 5, 2023
概括
睡眠特征的组合,如失眠和睡眠短暂会增加急性心肌梗塞 (AMI) 风险,尽管效果似乎独立. 长时间睡眠并没有提高AMI风险在这个因数门德尔随机化研究.
科学领域:
- 心血管流行病学心血管流行病学
- 睡眠科学 睡眠科学
- 遗传流行病学遗传流行病学
背景情况:
- 关于睡眠特征对急性心肌梗塞 (AMI) 风险的综合影响的研究有限.
- 在此之前,没有应用过因数门德尔随机化 (MR) 来研究这些联合效应,因此有机会减轻混和偏见.
- 了解这些关系对于开发有针对性的睡眠干预措施来减少AMI发病率至关重要.
研究的目的:
- 使用因子 MR 调查两种睡眠特征 (失眠症状,睡眠时间,时间型) 和AMI风险的组合之间的因果相互作用.
- 评估睡眠特征对AMI风险的影响是独立的还是相互作用的.
- 为了确定与改变的AMI风险相关的特定睡眠特征组合.
主要方法:
- 采用2x2因数门德尔随机化设计,使用失眠症状,睡眠时间和时间型的遗传风险得分.
- 使用了来自英国生物库 (UKBB) 和特伦德拉格健康研究 (HUNT2) 的数据.
- 遗传风险得分在中位数被二分化,并分析了特征的组合,以估计AMI风险.
主要成果:
- 在UKBB中,具有不眠症症状和睡眠短暂的高遗传风险的个体显示出AMI风险最高 (HR 1.10).
- 早晨慢型的高遗传风险与失眠症状或睡眠短暂相结合,也增加了UKBB的AMI风险 (HR分别为1.09和1.11).
- 在任何一个队列中都没有观察到睡眠特征与AMI风险之间的相互作用的统计学意义上的证据.
结论:
- 虽然没有发现显著的相互作用,但某些睡眠特征的组合 (不包括长时间睡眠) 与AMI风险增加有关.
- 这些发现表明,个人睡眠特征对AMI风险的主要影响可能是独立的.
- 这些结果强调了解决个人睡眠问题的重要性,以减轻心血管风险.
相关概念视频
Insufficient Sleep and Sleep Deprivation
151
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
151
Substance Use Disorders Affecting Sleep
180
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
180
Cause and Effect
10.9K
While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
10.9K
Coronary Artery Disease I: Introduction
19
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
19
Factors Influencing Heart Rate
2.7K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
2.7K
Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K


